Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca 2+ /Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway
نویسندگان
چکیده
منابع مشابه
Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway.
We have recently demonstrated that hydrogen peroxide (H(2)O(2)) is an extremely potent stimulus of endothelial NO synthase (eNOS) gene expression. The present study was designed to identify the signaling mechanisms mediating this response. Induction of eNOS expression by H(2)O(2) was found to be Ca(2+) dependent, inasmuch as it was blocked by BAPTA-AM. Further studies have indicated that Ca(2+)...
متن کاملInduction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca/Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway
We have recently demonstrated that hydrogen peroxide (H2O2) is an extremely potent stimulus of endothelial NO synthase (eNOS) gene expression. The present study was designed to identify the signaling mechanisms mediating this response. Induction of eNOS expression by H2O2 was found to be Ca 21 dependent, inasmuch as it was blocked by BAPTA-AM. Further studies have indicated that Ca/calmodulin-d...
متن کاملA Brain - specific Ca 2 + / Calmodulin - dependent Protein Kinase ( CaM Kinase - Gr ) Is Regulated by Autophosphorylation
A neuronal Ca2+/calmodulin-dependent protein kinase (CaM kinase-Gr) undergoes autophosphorylation on a serine residue(s) in response to Ca2+ and calmodulin. Phosphate incorporation leads to the formation of a Ca2+-independent (autonomous) activity state, as well as potentiation of the Ca’+/calmodulin-dependent response. The autonomous enzyme activity of the phosphorylated enzyme approximately e...
متن کاملHydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.
Endothelial nitric-oxide synthase (eNOS) is an important component of vascular homeostasis. During vascular disease, endothelial cells are exposed to excess reactive oxygen species that can alter cellular phenotype by inducing various signaling pathways. In the current study, we examined the implications of H(2)O(2)-induced signaling for eNOS phosphorylation status and activity in porcine aorti...
متن کاملCa 2 - Calmodulin - dependent Protein Kinase II Potentiates
A rise in intracellular Ca (Ca i) mediates various cellular functions ranging from fertilization to gene expression. A ubiquitous Ca influx pathway that contributes significantly to the generation of Ca i signals, especially in non-excitable cells, is store-operated Ca entry (SOCE). Consequently, the modulation of SOCE current affects Ca i dynamics and thus the ensuing cellular response. Theref...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2001
ISSN: 1079-5642,1524-4636
DOI: 10.1161/hq1001.097028